Amino Acid Molecular Units: Building Primary and Secondary Protein Structures
نویسندگان
چکیده
منابع مشابه
Patterns, structures, and amino acid frequencies in structural building blocks, a protein secondary structure classification scheme.
To study local structures in proteins, we previously developed an autoassociative artificial neural network (autoANN) and clustering tool to discover intrinsic features of macromolecular structures. The hidden unit activations computed by the trained autoANN are a convenient low-dimensional encoding of the local protein backbone structure. Clustering these activation vectors results in a unique...
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Benoit GRANIER,* Colette DUEZ,* Sophie LEPAGE,* Serge ENGLEBERT,* Jean DUSART,*T Otto DIDEBERG,* Jozef VAN BEEUMEN,t Jean-Marie FRERE* and Jean-Marie GHUYSEN* *Centre d'Ingenierie des Proteines, Universite de Liege, Institut de Chimie, B6, B-4000 Sart Tilman (Liege 1), and tLaboratorium voor Microbiologie en Microbiele Genetica, Rijksuniversiteit-Gent, K.L. Ledeganckstraat 35, B-9000 Gent, Belgium
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Protein structures cluster into families of folds that can result from extremely different amino acid sequences [1]. Because the enormous amount of genetic information generates a limited number of protein folds [2], a particular domain structure often assumes numerous functions. How new protein structures and new functions evolve under these limitations remains elusive. Molecular evolution may...
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ژورنال
عنوان ژورنال: Revista de Ensino de Bioquímica
سال: 2008
ISSN: 2318-8790
DOI: 10.16923/reb.v6i1.93